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Nat Cell Biol. 2016 Aug;18(8):823-32. doi: 10.1038/ncb3385. Epub 2016 Jul 18.

Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing.

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Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611-2909, USA.
The Buck Institute for Research on Aging, Novato, California 94945-1400, USA, and the Leibniz Institute on Aging-Fritz Lipmann Institute, Jena 07745, Germany.
Department of Medicine, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, California 94143-0667, USA.


Many tissues and organ systems in metazoans have the intrinsic capacity to regenerate, which is driven and maintained largely by tissue-resident somatic stem cell populations. Ageing is accompanied by a deregulation of stem cell function and a decline in regenerative capacity, often resulting in degenerative diseases. The identification of strategies to maintain stem cell function and regulation is therefore a promising avenue to allay a wide range of age-related diseases. Studies in various organisms have revealed a central role for metabolic pathways in the regulation of stem cell function. Ageing is associated with extensive metabolic changes, and interventions that influence cellular metabolism have long been recognized as robust lifespan-extending measures. In this Review, we discuss recent advances in our understanding of the metabolic control of stem cell function, and how stem cell metabolism relates to homeostasis and ageing.

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