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Dermatol Surg. 2016 Sep;42(9):1094-101. doi: 10.1097/DSS.0000000000000704.

Repeated OnabotulinumtoxinA Treatment of Glabellar Lines at Rest Over Three Treatment Cycles.

Author information

1
Departments of *Dermatology and Skin Science, and †Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada; ‡Private Practice, Boca Raton, Florida; §Department of Clinical Development, Allergan plc, Irvine, California; ¶Department of Neurology, University of California, Irvine, California.

Abstract

BACKGROUND:

OnabotulinumtoxinA has demonstrated the ability to eliminate mild glabellar lines at rest; however, less is known regarding the effect of repeat treatment on more severe lines at rest.

OBJECTIVE:

To assess the effect of repeated onabotulinumtoxinA treatment for reduction of glabellar lines at rest.

METHODS:

Subjects 18 to 75 years old with at least mild glabellar lines at rest, as assessed by the validated Facial Wrinkle Scale (FWS) with photonumeric guide (score ≥ 1), received 3 treatments of 20 U onabotulinumtoxinA 4 months apart (N = 225). "Response" was defined as elimination of glabellar lines at rest (FWS score = 0) at any time point (Days 7, 30, 60, 90, and 120). Effect of treatment cycle on response was analyzed using repeated measures logistic regressions (p < .05).

RESULTS:

Most subjects were female (85%) and white (88%) (age range: 35-54 years). The likelihood of significant response was as follows: for all subjects combined (odds ratio [OR]: 1.31), for subjects with mild resting lines at baseline (OR: 1.49), and for older women (≥55 years) with mild resting lines at baseline (OR: 2.22). Of all subjects, 76% responded after 1 treatment, and 45% responded in all 3 cycles.

CONCLUSION:

Subjects repeatedly treated with onabotulinumtoxinA showed progressive improvement in glabellar lines at rest.

PMID:
27427996
PMCID:
PMC5414762
DOI:
10.1097/DSS.0000000000000704
[Indexed for MEDLINE]
Free PMC Article

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