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Clin Microbiol Infect. 2016 Dec;22(12):975-983. doi: 10.1016/j.cmi.2016.07.007. Epub 2016 Jul 15.

Functional balance between neuraminidase and haemagglutinin in influenza viruses.

Author information

1
Université Lyon, Université Lyon 1, Faculté de Médecine Lyon Est, CIRI Inserm U1111, équipe Virpath, Lyon, France; Hospices Civils de Lyon, Centre National de Référence virus influenzae France Sud, Laboratoire de Virologie, Groupement Hospitalier Nord, Lyon, France.
2
Université Lyon, Université Lyon 1, Faculté de Médecine Lyon Est, CIRI Inserm U1111, équipe Virpath, Lyon, France.
3
Université Lyon, Université Lyon 1, Faculté de Médecine Lyon Est, CIRI Inserm U1111, équipe Virpath, Lyon, France; Hospices Civils de Lyon, Centre National de Référence virus influenzae France Sud, Laboratoire de Virologie, Groupement Hospitalier Nord, Lyon, France. Electronic address: vanessa.escuret@chu-lyon.fr.

Abstract

Seasonal influenza A and B viruses are important human pathogens responsible for significant morbidity and mortality worldwide. In addition, influenza A zoonotic viruses are a constant pandemic threat. These viruses present two major surface glycoproteins: the haemagglutinin (HA) and the neuraminidase (NA). These two glycoproteins both recognize the sialic acid and have complementary activities, the HA binds the sialic acid through its receptor-binding site, the NA is a receptor-destroying enzyme that cleaves α2-3 and α2-6-linked sialic acids. Therefore, the functional HA/NA balance is a critical factor for a good viral fitness and plays a major role in overcoming the host barrier and the efficiency of sustained human-to-human transmission. Although the two glycoproteins are in constant evolution, the HA/NA balance seems to remain stable in human viruses because an optimal balance is required to maintain good viral fitness. Understanding the evolution of influenza viruses requires an in-depth exploration of the HA/NA balance.

KEYWORDS:

Antiviral resistance; Haemagglutinin; Haemagglutinin/Neuraminidase balance; Host adaptation; Influenza viruses; Neuraminidase

PMID:
27424943
DOI:
10.1016/j.cmi.2016.07.007
[Indexed for MEDLINE]
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