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Diabetologia. 2016 Oct;59(10):2193-202. doi: 10.1007/s00125-016-4055-8. Epub 2016 Jul 16.

Lactation is associated with altered metabolomic signatures in women with gestational diabetes.

Much D1,2,3,4, Beyerlein A1,4, Kindt A4,5, Krumsiek J4,5, Stückler F4,5, Rossbauer M1,2,3, Hofelich A1,4, Wiesenäcker D1,2,6, Hivner S1,2,3,4, Herbst M1,2,3,4, Römisch-Margl W4,7, Prehn C8, Adamski J4,8,9, Kastenmüller G4,7, Theis F4,5, Ziegler AG1,2,3,4, Hummel S10,11,12,13.

Author information

1
Institute of Diabetes Research, Helmholtz Zentrum München, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.
2
Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
3
Forschergruppe Diabetes e.V., Neuherberg, Germany.
4
German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.
5
Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.
6
Department of Pediatrics, Kinderklinik München Schwabing, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
7
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Neuherberg, Germany.
8
Genome Analysis Center, Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
9
Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany.
10
Institute of Diabetes Research, Helmholtz Zentrum München, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany. sandra.hummel@helmholtz-muenchen.de.
11
Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Munich, Germany. sandra.hummel@helmholtz-muenchen.de.
12
Forschergruppe Diabetes e.V., Neuherberg, Germany. sandra.hummel@helmholtz-muenchen.de.
13
German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany. sandra.hummel@helmholtz-muenchen.de.

Abstract

AIMS/HYPOTHESIS:

Lactation for >3 months in women with gestational diabetes is associated with a reduced risk of type 2 diabetes that persists for up to 15 years postpartum. However, the underlying mechanisms are unknown. We examined whether in women with gestational diabetes lactation for >3 months is associated with altered metabolomic signatures postpartum.

METHODS:

We enrolled 197 women with gestational diabetes at a median of 3.6 years (interquartile range 0.7-6.5 years) after delivery. Targeted metabolomics profiles (including 156 metabolites) were obtained during a glucose challenge test. Comparisons of metabolite concentrations and ratios between women who lactated for >3 months and women who lactated for ≤3 months or not at all were performed using linear regression with adjustment for age and BMI at the postpartum visit, time since delivery, and maternal education level, and correction for multiple testing. Gaussian graphical modelling was used to generate metabolite networks.

RESULTS:

Lactation for >3 months was associated with a higher total lysophosphatidylcholine/total phosphatidylcholine ratio; in women with short-term follow-up, it was also associated with lower leucine concentrations and a lower total branched-chain amino acid concentration. Gaussian graphical modelling identified subgroups of closely linked metabolites within phosphatidylcholines and branched-chain amino acids that were affected by lactation for >3 months and have been linked to the pathophysiology of type 2 diabetes in previous studies.

CONCLUSIONS/INTERPRETATION:

Lactation for >3 months in women with gestational diabetes is associated with changes in the metabolomics profile that have been linked to the early pathogenesis of type 2 diabetes.

KEYWORDS:

Gestational diabetes; Lactation; Metabolic networks; Metabolomic profile; Type 2 diabetes

PMID:
27423999
DOI:
10.1007/s00125-016-4055-8
[Indexed for MEDLINE]

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