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Semin Cell Dev Biol. 2016 Dec;60:5-9. doi: 10.1016/j.semcdb.2016.07.014. Epub 2016 Jul 14.

Developmental roles of Rhomboid proteases.

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Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address:


Rhomboid proteins have emerged as one of the most tantalizing and diverse families of proteases. Gene duplication events and structural alterations have sculpted the varied roles of this protein family, maintaining a conserved structural core throughout the bacterial, plant and animal kingdoms. Unresolved questions pop up at many junctions. This review will focus on a distinct class of Rhomboid proteins that plays an essential role in development. It will outline the diverse mechanisms by which these proteins are regulated, and the implications on the biological processes they control. While most of the review will deal with Rhomboids in Drosophila, a system that has been studied in the greatest detail, it will also explore parallels and differences in the function of Rhomboids in the flour beetle T. casteneum and the worm C. elegans.


Drosophila; EGF receptor; Endoplasmic reticulum; Ligand processing; Rhomboid; Spitz; Star

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