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Neuroimaging Clin N Am. 2016 Aug;26(3):373-416. doi: 10.1016/j.nic.2016.03.007.

The Pediatric Cerebellum in Inherited Neurodegenerative Disorders: A Pattern-recognition Approach.

Author information

1
Division of Paediatric Neuroradiology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada. Electronic address: susan.blaser@sickkids.ca.
2
Division of Neuropaediatrics, Development and Rehabilitation, University Children's Hospital Inselspital, University of Bern, Freiburgstrasse 4, Bern 3010, Switzerland.
3
Department of Genetics, Sultan Qaboos University Hospital, Al Khoudh, Muscat 123, Oman.
4
Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.

Abstract

Evaluation of imaging studies of the cerebellum in inherited neurodegenerative disorders is aided by attention to neuroimaging patterns based on anatomic determinants, including biometric analysis, hyperintense signal of structures, including the cerebellar cortex, white matter, dentate nuclei, brainstem tracts, and nuclei, the presence of cysts, brain iron, or calcifications, change over time, the use of diffusion-weighted/diffusion tensor imaging and T2*-weighted sequences, magnetic resonance spectroscopy; and, in rare occurrences, the administration of contrast material.

KEYWORDS:

Cerebellum; Inborn errors of metabolism; Inherited neurodegenerative disorders

PMID:
27423800
DOI:
10.1016/j.nic.2016.03.007
[Indexed for MEDLINE]

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