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Trends Genet. 2016 Sep;32(9):523-525. doi: 10.1016/j.tig.2016.06.002. Epub 2016 Jul 13.

Outgroups and Positive Selection: The Nothobranchius furzeri Case.

Author information

1
Leibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany.
2
Leibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany; Laboratory of Biology Bio@SNS, Scuola Normale Superiore, Pisa, Italy. Electronic address: alessandro.cellerino@sns.it.

Abstract

Applications of positive selection analysis increase with the number of species for which genome/transcriptome sequences become available. Using the recently sequenced turquoise killifish (Nothobranchius furzeri) genome as an example, we compare two different approaches based on different outgroup selection. The combination of these two methods allows the origin of positively selected sites in aging-related genes of the N. furzeri genome to be determined.

PMID:
27423541
DOI:
10.1016/j.tig.2016.06.002
[Indexed for MEDLINE]

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