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Clin Immunol. 2016 Sep;170:1-8. doi: 10.1016/j.clim.2016.07.010. Epub 2016 Jul 13.

Group 2 innate lymphoid cells are increased in nasal polyps in patients with eosinophilic chronic rhinosinusitis.

Author information

1
Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Japan. Electronic address: itirotz@hotmail.com.
2
Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Japan.
3
Division of Allergic Diseases, Department of Internal Medicine, and the Department of Immunology, Mayo Clinic, Rochester, MN, United States.

Abstract

ILC2s represent a critical innate cellular source of type 2 cytokines and may play important roles in various diseases. We examined the role of ILC2s in the pathogenesis of two subgroups of CRSwNP: ECRS and non-ECRS. We analyzed the prevalence of ILC2s in sinonasal tissues and in blood from patients with ECRS, non-ECRS, CRSsNP, and control. The prevalence of ILC2s in nasal tissues was higher in patients with ECRS as compared to those with non-ECRS or CRSsNP. The prevalence of blood ILC2s was not different between patients with ECRS and non-ECRS. The prevalence of blood ILC2s was higher in patients with allergic rhinitis and elevated serum IgE levels. Alternaria-induced IL-33 secretion was increased in nasal epithelial cells derived from patients with ECRS as compared to those from patients with non-ECRS or CRSsNP. ILC2s may be involved in the pathogenesis of CRSwNP, in particular in patients with tissue eosinophilia (i.e., ECRS).

KEYWORDS:

Allergic rhinitis; Alternaria; Asthma; Eosinophilic chronic rhinosinusitis; Group 2 innate lymphoid cells; IL-33

PMID:
27422491
DOI:
10.1016/j.clim.2016.07.010
[Indexed for MEDLINE]

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