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Semin Cell Dev Biol. 2016 Dec;60:97-104. doi: 10.1016/j.semcdb.2016.07.009. Epub 2016 Jul 12.

SNARE-mediated membrane fusion in autophagy.

Author information

1
Center for Mitochondrial Biology and Medicine, Ministry of Education Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
2
Center for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; State Key Lab of Animal Nutrition, China Agricultural University, Beijing 100193, China.
3
Center for Mitochondrial Biology and Medicine, Ministry of Education Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
4
Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA.
5
Center for Mitochondrial Biology and Medicine, Ministry of Education Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China. Electronic address: jglong@xjtu.edu.cn.
6
Center for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: qing.zhong@utsouthwestern.edu.
7
Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address: jiajie.diao@uc.edu.

Abstract

Autophagy, a conserved self-eating process for the bulk degradation of cytoplasmic materials, involves double-membrane autophagosomes formed when an isolation membrane emerges and their direct fusion with lysosomes for degradation. For the early biogenesis of autophagosomes and their later degradation in lysosomes, membrane fusion is necessary, although different sets of genes and autophagy-related proteins involved in distinct fusion steps have been reported. To clarify the molecular mechanism of membrane fusion in autophagy, to not only expand current knowledge of autophagy, but also benefit human health, this review discusses key findings that elucidate the unique membrane dynamics of autophagy.

KEYWORDS:

Autophagy; Membrane fusion; SNARE

PMID:
27422330
PMCID:
PMC5161566
DOI:
10.1016/j.semcdb.2016.07.009
[Indexed for MEDLINE]
Free PMC Article

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