Format

Send to

Choose Destination
J Allergy Clin Immunol Pract. 2016 Sep-Oct;4(5):956-62. doi: 10.1016/j.jaip.2016.04.009. Epub 2016 Jul 12.

Food Allergy Sensitization and Presentation in Siblings of Food Allergic Children.

Author information

1
Smith Child Health Research Program, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill; Northwestern University Feinberg School of Medicine, Chicago, Ill. Electronic address: r-gupta@northwestern.edu.
2
Smith Child Health Research Program, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill.
3
Department of Pediatrics, Allergy Section, Children's Hospital Colorado, University of Colorado Denver School of Medicine, Denver, Colo.
4
Northwestern University Feinberg School of Medicine, Chicago, Ill.
5
Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md.
6
Northwestern University Feinberg School of Medicine, Chicago, Ill; Edward J. Hines Jr. VA Hospital, Spinal Cord Injury QUERI, Center for Management of Complex Chronic Care, Hines, Ill.

Abstract

BACKGROUND:

Many parents of food allergic children have concerns about the development of food allergies in their other children.

OBJECTIVE:

We sought to determine prevalence of food sensitization and clinical food allergy among siblings of food allergic children.

METHODS:

Two thousand eight hundred and thirty-four children were enrolled in the Chicago Family Cohort Food Allergy study. One thousand one hundred and twenty children (ages 0-21 years) with a food allergy (defined by a reported reaction history and evidence of food-specific IgE or skin prick test) and at least 1 biological sibling were included in this study.

RESULTS:

Among siblings of children with food allergy, 33.4% had no sensitization and no clinical symptoms to food. Fifty-three percent had a positive food serum-specific IgE or skin prick test, but no reported symptoms of food allergy. Only 13.6% of siblings were both sensitized and clinically reactive to the same food. Milk allergy was the most common allergy among siblings (5.9%), followed by egg allergy (4.4%) and peanut allergy (3.7%).

CONCLUSIONS:

In a large cohort of food allergic families, only a small proportion of siblings were both sensitized and clinically reactive to a food. Sensitization without reactivity was common among siblings. Testing for food allergy in siblings without a history of clinical reactivity appears to be unjustified. Screening may lead to negative consequences related to potential misdiagnosis and unnecessary avoidance of a food. More data are needed to determine the absolute risk of food allergy development in siblings of food allergic children.

KEYWORDS:

Childhood food allergy; ImmunoCAP; Milk allergy; Peanut allergy; Risk; Sensitization; Siblings; Skin testing

PMID:
27421900
PMCID:
PMC5010481
DOI:
10.1016/j.jaip.2016.04.009
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center