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Anesth Analg. 1989 Jul;69(1):87-92.

Acute acid aspiration lung injury in the rat: biphasic pathogenesis.

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Department of Anesthesiology, University of Michigan Medical Center, Ann Arbor 48109.


The purpose of this study was to develop a reproducible model of acute acid aspiration-induced lung injury in the rat to explore the pathophysiology of aspiration pneumonitis. A biphasic injury pattern was observed with injury peaks at 1 hr and 4 hr. Histologic studies at 4 hr revealed significant increases in neutrophils in the alveolar interstitial space. These studies suggest that acid aspiration results in a biphasic acute injury. We hypothesize that the first phase results from a direct physiochemical process or is mediated via afferent (capsaicin sensitive) nerves or both. The second phase, occurring 2-3 hr later, is mediated by neutrophils and is consistent with an acute inflammatory response.

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