Format

Send to

Choose Destination
Reprod Toxicol. 2017 Mar;68:164-170. doi: 10.1016/j.reprotox.2016.07.010. Epub 2016 Jul 12.

Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances.

Author information

1
Department of Environmental Medicine, University of Southern Denmark, J.B. Winsløws Vej 17A, 5000 Odense C, Denmark. Electronic address: atimmermann@health.sdu.dk.
2
Section of Biostatistics, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen K, Denmark. Electronic address: zrg272@ku.dk.
3
Department of Occupational Medicine and Public Health, Sigmundargøta 5, 100 Tórshavn, Faroe Islands, Denmark. Electronic address: maria@health.fo.
4
Department of Occupational Medicine and Public Health, Sigmundargøta 5, 100 Tórshavn, Faroe Islands, Denmark; Faculty of Natural and Health Sciences, University of The Faroe Islands, J.C. Svabos gøta 14, 100 Tórshavn, Faroe Islands, Denmark. Electronic address: pal@health.fo.
5
Department of Occupational Medicine and Public Health, Sigmundargøta 5, 100 Tórshavn, Faroe Islands, Denmark. Electronic address: usteuerwald@web.de.
6
Department of Environmental Medicine, University of Southern Denmark, J.B. Winsløws Vej 17A, 5000 Odense C, Denmark. Electronic address: FNielsen@health.sdu.dk.
7
Department of Environmental Medicine, University of Southern Denmark, J.B. Winsløws Vej 17A, 5000 Odense C, Denmark. Electronic address: tkjensen@health.sdu.dk.
8
Department of Environmental Medicine, University of Southern Denmark, J.B. Winsløws Vej 17A, 5000 Odense C, Denmark; Department of Environmental Health, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, United States. Electronic address: PGrandjean@health.sdu.dk.

Abstract

The aim of this study was to determine whether maternal exposure to persistent perfluoroalkyl substances (PFASs) affect the capability to breastfeed. In two Faroese birth cohorts (N=1130), concentrations of five PFASs were measured in maternal serum during pregnancy or two weeks after term. Duration of breastfeeding was assessed by questionnaire and clinical interview. In adjusted linear regression models, a doubling of maternal serum PFASs was associated with a reduction in duration of both total and exclusive breastfeeding, most pronounced for perfluorooctane sulfonic acid (PFOS) where a doubling was associated with a reduction in total breastfeeding of 1.4 (95% CI: 0.6; 2.1) months and perfluorooctanoic acid (PFOA) where a doubling was associated with a reduction in exclusive breastfeeding of 0.5 (0.3; 0.7) months. The associations were evident among both primiparous and multiparous women, and thus cannot be explained by confounding from previous breastfeeding.

KEYWORDS:

Breast milk; Breastfeeding; Endocrine disruption; Lactation; Maternal health; Perfluoroalkyl substances

PMID:
27421579
PMCID:
PMC5233673
DOI:
10.1016/j.reprotox.2016.07.010
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center