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Reprod Toxicol. 2017 Mar;68:119-129. doi: 10.1016/j.reprotox.2016.07.009. Epub 2016 Jul 12.

Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats.

Author information

1
Department of Environmental Toxicology, University of California at Davis, Davis, CA, USA.
2
Department of Nutrition, University of California at Davis, Davis, CA, USA.
3
Department of Nutrition, University of California at Davis, Davis, CA, USA; West Coast Metabolomics Center, University of California at Davis, Davis, CA, USA.
4
Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, CA, USA.
5
Department of Nutrition, University of California at Davis, Davis, CA, USA; West Coast Metabolomics Center, University of California at Davis, Davis, CA, USA; Obesity and Metabolism Research Unit, USDA-ARS Western Human Nutrition Research Center, Davis, CA, USA.
6
Department of Nutrition, University of California at Davis, Davis, CA, USA; Department of Molecular Biosciences, School of Veterinary Medicine, University of California at Davis, Davis, CA, USA.
7
Department of Environmental Toxicology, University of California at Davis, Davis, CA, USA. Electronic address: mlamerrill@ucdavis.edu.

Abstract

Triphenyl phosphate (TPhP) is a flame retardant additive frequently found in consumer products and household dust. We administered 170μg of TPhP in maternal food from gestational day 8.5 to weaning and evaluated metabolic phenotypes of 3.5 month old male and female rats, and weight-matched males up to 6 months, to assess the development of obesity and type 2 diabetes mellitus (T2DM), respectively. Perinatal TPhP exposure increased body and fat mass in 3.5 month old male and female rats, while leptin and cumulative energy intake were elevated in males and females, respectively. Independent of body mass, perinatal TPhP exposure accelerated T2DM onset in males and increased plasma non-esterified- fasting fatty acids. These observations suggest that perinatal exposure to TPhP exacerbates the development of obesity in male and female UCDavis-T2DM rats and accelerates T2DM onset in male UCD-T2DM rats.

KEYWORDS:

Developmental exposure; Diabetes mellitus; Firemaster 550; Hyperphagia; Leptin; Obesity; Triphenyl phosphate

PMID:
27421578
PMCID:
PMC5233641
DOI:
10.1016/j.reprotox.2016.07.009
[Indexed for MEDLINE]
Free PMC Article

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