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Expert Rev Clin Pharmacol. 2016 Oct;9(10):1341-1349. doi: 10.1080/17512433.2016.1213131. Epub 2016 Jul 28.

Management of drug hypersensitivity in the pediatric population.

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a Department of Allergology and Pulmonology , University Children's Hospital of Belgrade , Belgrade , Serbia.
b Medical Faculty University of Belgrade , Belgrade , Serbia.
c Department of Child and Adolescent , University Hospital of Geneva and Medical School of The University of Geneva , Geneva , Switzerland.


Several recent studies confirmed that drug allergy in children is over diagnosed, which is a major public health problem, and results in use of alternative drugs, increasing resistance and health costs. Areas covered: Articles in English with data on drug hypersensitivity in children were identified by searching the databases of MEDLINE (National Library of Medicine) from 1990 till 2016. Expert commentary: It is crucial to make a precise diagnosis with performing a complete allergy work-up based on carefully selected diagnostic tests depending on whether an immediate or a non-immediate reaction is suspected. The drug provocation test remains the gold standard in diagnostic drug hypersensitivity in children.


Allergy; children; drug hypersensitivity; drug provocation tests; immediate reactions; non-immediate reactions; non-steroidal anti-inflammatory drugs; non-β-lactam antibiotics; skin tests; β-lactam antibiotics

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