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Cancers (Basel). 2016 Jul 13;8(7). pii: E65. doi: 10.3390/cancers8070065.

Mammary Development and Breast Cancer: A Wnt Perspective.

Author information

1
State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. cissyyu@sibcb.ac.cn.
2
Department of Molecular Biology and Biochemistry, Centre for Cell Biology, Development and Disease, Simon Fraser University, Burnaby, BC V5A 1S6, Canada. everheye@sfu.ca.
3
State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. yzeng@sibcb.ac.cn.

Abstract

The Wnt pathway has emerged as a key signaling cascade participating in mammary organogenesis and breast oncogenesis. In this review, we will summarize the current knowledge of how the pathway regulates stem cells and normal development of the mammary gland, and discuss how its various components contribute to breast carcinoma pathology.

KEYWORDS:

Wnt; breast cancer; development; mammary gland; stem cells

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