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Chem Commun (Camb). 2016 Aug 14;52(63):9801-4. doi: 10.1039/c6cc02387h. Epub 2016 Jul 15.

Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (<250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry.

Author information

1
Center for Biotechnology and Department for Proteome and Metabolome Research, Faculty of Biology, Bielefeld University, Universitätsstr. 25, 33615 Bielefeld, Germany. kniehaus@cebitec.uni-bielefeld.de.

Abstract

A novel vacuum stable proton sponge, 4-maleicanhydridoproton sponge (MAPS), was prepared and applied as the matrix in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) of an aggressive brain tumor tissue (glioblastoma multiforme). Ionic maps of lactate, 2-hydroxyglutarate and chloride anions (m/z 89, 147, 35, respectively) were obtained using a routine MALDI ToF mass spectrometer.

PMID:
27419250
DOI:
10.1039/c6cc02387h
[Indexed for MEDLINE]

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