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Microvasc Res. 2016 Nov;108:29-33. doi: 10.1016/j.mvr.2016.07.004. Epub 2016 Jul 11.

Anti-inflammatory and angiogenic activity of polysaccharide extract obtained from Tibetan kefir.

Author information

1
Faculdades Pequeno Príncipe, Curitiba, PR, Brazil. Electronic address: mrosaprado@hotmail.com.
2
Faculdades Pequeno Príncipe, Curitiba, PR, Brazil.
3
Faculdades Pequeno Príncipe, Curitiba, PR, Brazil; Instituto de Pesquisa Pelé Pequeno Príncipe de Pesquisa, Curitiba, PR, Brazil.
4
Instituto de Pesquisa Pelé Pequeno Príncipe de Pesquisa, Curitiba, PR, Brazil.
5
Instituto de Tecnologia do Paraná, Paraná, Curitiba, PR, Brazil.
6
Universidade Federal do Paraná, Curitiba, PR, Brazil.

Abstract

The search for new bioactive molecules is a driving force for research pharmaceutical industries, especially those molecules obtained from fermentation. The molecules possessing angiogenic and anti-inflammatory attributes have attracted attention and are the focus of this study. Angiogenic activity from kefir polysaccharide extract, via chorioallantoic membrane assay, exhibited a pro-angiogenic effect compared with vascular endothelial factor (pro-angiogenic) and hydrocortisone (anti-angiogenic) activity as standards with an EC50 of 192ng/mL. In terms of anti-inflammatory activity determined via hyaluronidase enzyme assay, kefir polysaccharide extract inhibited the enzyme with a minimal activity of 2.08mg/mL and a maximum activity of 2.57mg/mL. For pharmaceutical purposes, kefir polysaccharide extract is considered to be safe because it does not inhibit VERO cells in cytotoxicity assays.

KEYWORDS:

Angiogenic activity; Anti-inflammatory activity; Hyaluronidase; Tibetan kefir

PMID:
27418582
DOI:
10.1016/j.mvr.2016.07.004
[Indexed for MEDLINE]

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