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Methods Mol Biol. 2016;1467:1-14. doi: 10.1007/978-1-4939-4023-3_1.

WT1 Mutation in Childhood Cancer.

Author information

1
UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
2
UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK. k.pritchard-jones@ucl.ac.uk.
3
Hugh and Catherine Stevenson Professor of Paediatric Oncology, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK. k.pritchard-jones@ucl.ac.uk.

Abstract

In this chapter, the role of WT1 in childhood cancer is discussed, using the key examples Wilms' tumor, desmoplastic small round cell of childhood, and leukemia. The role of WT1 in each disease is described and mirrored to the role of WT1 in normal development.

KEYWORDS:

Childhood cancer; Desmoplastic small round cell tumor of childhood; Development; Leukemia; Minimal residual disease; Wilms’ tumor

PMID:
27417955
DOI:
10.1007/978-1-4939-4023-3_1
[Indexed for MEDLINE]

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