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Fertil Steril. 2016 Sep 15;106(4):827-56. doi: 10.1016/j.fertnstert.2016.06.027. Epub 2016 Jul 12.

Evidence for bisphenol A-induced female infertility: a review (2007-2016).

Author information

1
School of Food and Nutrition, Massey University, Palmerston North, New Zealand.
2
Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois. Electronic address: jflaws@illinois.edu.

Abstract

We summarized the scientific literature published from 2007 to 2016 on the potential effects of bisphenol A (BPA) on female fertility. We focused on overall fertility outcomes (e.g., ability to become pregnant, number of offspring), organs that are important for female reproduction (i.e., oviduct, uterus, ovary, hypothalamus, and pituitary), and reproductive-related processes (i.e., estrous cyclicity, implantation, and hormonal secretion). The reviewed literature indicates that BPA may be associated with infertility in women. Potential explanations for this association can be generated from experimental studies. Specifically, BPA may alter overall female reproductive capacity by affecting the morphology and function of the oviduct, uterus, ovary, and hypothalamus-pituitary-ovarian axis in animal models. In addition, BPA may disrupt estrous cyclicity and implantation. Nevertheless, further studies are needed to better understand the exact mechanisms of action and to detect potential reproductive toxicity at earlier stages.

KEYWORDS:

Infertility; bisphenol A; female; hypothalamus; implantation; ovary; pituitary; uterus

PMID:
27417731
PMCID:
PMC5026908
DOI:
10.1016/j.fertnstert.2016.06.027
[Indexed for MEDLINE]
Free PMC Article

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