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Science. 2016 Aug 12;353(6300):aaf8160. doi: 10.1126/science.aaf8160. Epub 2016 Jul 14.

Assessing the global threat from Zika virus.

Author information

1
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. justin@jhu.edu.
2
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
3
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
4
Department of Biology, Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
5
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Paris, France.
6
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
7
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
8
Department of Medicine, School of Public Health, Imperial College London, London, UK.
9
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA. Office of Population Research, Princeton University, Princeton, NJ, USA.

Abstract

First discovered in 1947, Zika virus (ZIKV) infection remained a little-known tropical disease until 2015, when its apparent association with a considerable increase in the incidence of microcephaly in Brazil raised alarms worldwide. There is limited information on the key factors that determine the extent of the global threat from ZIKV infection and resulting complications. Here, we review what is known about the epidemiology, natural history, and public health effects of ZIKV infection, the empirical basis for this knowledge, and the critical knowledge gaps that need to be filled.

PMID:
27417495
PMCID:
PMC5467639
DOI:
10.1126/science.aaf8160
[Indexed for MEDLINE]
Free PMC Article

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