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Clin Neurophysiol. 2016 Aug;127(8):2721-2727. doi: 10.1016/j.clinph.2016.05.006. Epub 2016 May 24.

Electroencephalographic characteristics of epileptic seizures in preterm neonates.

Author information

1
Department of Clinical Neurophysiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N JH, United Kingdom; Neurophysiology Department, Hôpital Trousseau, Assistance Publique Hôpitaux de Paris, Paris, France. Electronic address: sona.janackova@aphp.fr.
2
Department of Clinical Neurophysiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N JH, United Kingdom; Clinical Neuroscience, Institute of Child Health, University College London, London, UK.
3
Saul R. Korey Department of Neurology, Department of Pediatrics, Montefiore/Einstein Epilepsy Management Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.
4
Division of Neurophysiology, Epilepsy and Neurocritical Care Children's National Health System, George Washington University School of Medicine, USA.
5
Neurophysiology Department, CHRU Roger-Salengro, Lille, France.

Abstract

OBJECTIVE:

Although seizures are more common in the neonatal period than in any other stage of childhood, those in preterm neonates are still poorly described. The aim of this study was to assess electro-clinical characteristics of seizures occurring before a corrected age of 40weeks in neonates born prematurely.

METHOD:

Retrospective analysis of EEG-documented seizures in neonates born prematurely. Seizures in a group of term neonates served as controls.

RESULTS:

Fifty-six prematurely born and 46 term born neonates were included. Median duration of seizures was 52s in preterm and 96s in term neonates. Seizures were focal or multifocal. In least mature neonates, they involved smaller regions of onset and remained localised. With increasing corrected age, propagation became more frequent. The electrographic pattern - maximal frequency of oscillation and the onset pattern also evolved with age. Electro-clinical seizures were observed in 25% of preterm versus 50% of term neonates; almost all electro-clinical seizures involved the central (motor) regions.

CONCLUSION:

Ictal EEG features undergo changes depending on corrected age. Most seizures are subclinical, thus EEG is essential for diagnosis.

SIGNIFICANCE:

Relating ictal EEG pattern to corrected age can improve diagnosis and ultimately management.

KEYWORDS:

Electroencephalography; Epileptic seizures; Neonate; Preterm

PMID:
27417043
DOI:
10.1016/j.clinph.2016.05.006
[Indexed for MEDLINE]

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