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Euro Surveill. 2016 Jul 7;21(27). doi: 10.2807/1560-7917.ES.2016.21.27.30280.

Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016.

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1
Laboratory of Medical Microbiology, Wilrijk, Belgium.

Abstract

We identified a novel plasmid-mediated colistin-resistance gene in porcine and bovine colistin-resistant Escherichia coli that did not contain mcr-1. The gene, termed mcr-2, a 1,617 bp phosphoethanolamine transferase harboured on an IncX4 plasmid, has 76.7% nucleotide identity to mcr-1. Prevalence of mcr-2 in porcine colistin-resistant E. coli (11/53) in Belgium was higher than that of mcr-1 (7/53). These data call for an immediate introduction of mcr-2 screening in ongoing molecular epidemiological surveillance of colistin-resistant Gram-negative pathogens.

KEYWORDS:

Belgium; Escherichia coli; IncX4; colistin resistance; mcr-1; mcr-2; phosphoethanolamine transferase; pigs

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