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Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3759-68. doi: 10.1167/iovs.15-18313.

Bilateral Symmetry of Visual Function Loss in Cone-Rod Dystrophies.

Author information

1
Istituto di Neuroscienze Consiglio Nazionale delle Ricerche (CNR) Pisa, Italy.
2
Institute of Ophthalmology, Policlinico Gemelli, Catholic University, Rome, Italy.
3
Istituto di Fisiologia Clinica CNR, Pisa, Italy.
4
Bietti Foundation, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
5
Tecnologie e Salute, Istituto Superiore di Sanità, Rome, Italy.
6
MAGI Laboratory for Medical Genetics, Rovereto, Italy.
7
Istituto di Informatica e Telematica CNR, Pisa, Italy.

Abstract

PURPOSE:

To investigate bilateral symmetry of visual impairment in cone-rod dystrophy (CRD) patients and understand the feasibility of clinical trial designs treating one eye and using the untreated eye as an internal control.

METHODS:

This was a retrospective study of visual function loss measures in 436 CRD patients followed at the Ophthalmology Department of the Catholic University in Rome. Clinical measures considered were best-corrected visual acuity, focal macular cone electroretinogram (fERG), and Ganzfeld cone-mediated and rod-mediated electroretinograms. Interocular agreement in each of these clinical indexes was assessed by t- and Wilcoxon tests for paired samples, structural (Deming) regression analysis, and intraclass correlation. Baseline and follow-up measures were analyzed. A separate analysis was performed on the subset of 61 CRD patients carrying likely disease-causing mutations in the ABCA4 gene.

RESULTS:

Statistical tests show a very high degree of bilateral symmetry in the extent and progression of visual impairment in the fellow eyes of CRD patients.

CONCLUSIONS:

These data contribute to a better understanding of CRDs and support the feasibility of clinical trial designs involving unilateral eye treatment with the use of fellow eye as internal control.

PMID:
27415794
DOI:
10.1167/iovs.15-18313
[Indexed for MEDLINE]

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