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Open Forum Infect Dis. 2016 May 5;3(3):ofw086. doi: 10.1093/ofid/ofw086. eCollection 2016 Sep.

Donor-Derived Coccidioides immitis Endocarditis and Disseminated Infection in the Setting of Solid Organ Transplantation.

Author information

1
Division of Infectious Diseases and Geographic Medicine.
2
Montreal Heart Institute , Canada.
3
Department of Cardiovascular Medicine , Stanford University School of Medicine , California.

Abstract

BACKGROUND:

 Endocarditis is a rare manifestation of infection with Coccidioides. This is the first reported case of donor-derived Coccidioides endocarditis obtained from a heart transplant.

METHODS:

 We present a unique case of donor-derived Coccidioides immitis endocarditis and disseminated infection in a heart transplant patient. We also conducted a review of the literature to identify other cases of donor-derived coccidioidomycosis in solid organ transplant recipients and reviewed their clinical characteristics.

RESULTS:

 Fifteen prior cases of donor-derived coccidioidomycosis were identified. A majority of these cases were diagnosed by positive culture (83%). Mortality was high at 58%.

CONCLUSIONS:

 Clinicians should maintain a high index of suspicion for disseminated coccidioidomycosis in patients who received transplants with organs from donors with a history of residing in endemic regions.

KEYWORDS:

coccidioidomycosis; donor-derive; endocarditis; solid organ transplant

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