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Oxid Med Cell Longev. 2016;2016:2715718. doi: 10.1155/2016/2715718. Epub 2016 Jun 19.

Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice.

Author information

1
School of Medicine, Henan University, Kaifeng, Henan 475004, China.
2
School of Medicine, Henan University, Kaifeng, Henan 475004, China; Kaifeng Central Hospital, Kaifeng, Henan 475000, China.
3
Kaifeng Central Hospital, Kaifeng, Henan 475000, China.

Abstract

Obesity is prevalent worldwide and is a major risk factor for the development and progression of kidney disease. Hydrogen sulfide (H2S) plays an important role in renal physiological and pathophysiological processes. However, whether H2S is able to mitigate kidney injury induced by obesity in mice remains unclear. In this study, we demonstrated that H2S significantly reduced the accumulation of lipids in the kidneys of high fat diet- (HFD-) induced obese mice. The results of hematoxylin and eosin, periodic acid-Schiff, and Masson's trichrome staining showed that H2S ameliorated the kidney structure, decreased the extent of interstitial injury, and reduced the degree of kidney fibrosis in HFD-induced obese mice. We found that H2S decreased the expression levels of tumor necrosis factor-α, interleukin- (IL-) 6, and monocyte chemoattractant protein-1 but increased the expression level of IL-10. Furthermore, H2S treatment decreased the protein expression of p50, p65, and p-p65 in the kidney of HFD-induced obese mice. In conclusion, H2S is able to mitigate renal injury in HFD-induced obese mice through the reduction of kidney inflammation by downregulating the expression of nuclear factor-kappa B. H2S or its releasing compounds may serve as a potential therapeutic molecule for obesity-induced kidney injury.

PMID:
27413418
PMCID:
PMC4930816
DOI:
10.1155/2016/2715718
[Indexed for MEDLINE]
Free PMC Article

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