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J Clin Microbiol. 2016 Sep;54(9):2348-53. doi: 10.1128/JCM.00877-16. Epub 2016 Jul 13.

Coinfections of Zika and Chikungunya Viruses in Bahia, Brazil, Identified by Metagenomic Next-Generation Sequencing.

Author information

1
Laboratory of Virology, Health Institute of Science, Federal University of Bahia, Salvador, Bahia, Brazil.
2
Department of Laboratory Medicine, University of California, San Francisco, California, USA UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, USA.
3
Aliança Hospital, Salvador, Bahia, Brazil.
4
Gonçalo Moniz Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, Bahia, Brazil.
5
Department of Laboratory Medicine, University of California, San Francisco, California, USA UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, USA Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, California, USA charles.chiu@ucsf.edu.

Abstract

Metagenomic next-generation sequencing (mNGS) of samples from 15 patients with documented Zika virus (ZIKV) infection in Bahia, Brazil, from April 2015 to January 2016 identified coinfections with chikungunya virus (CHIKV) in 2 of 15 ZIKV-positive cases by PCR (13.3%). While generally nonspecific, the clinical presentation corresponding to these two CHIKV/ZIKV coinfections reflected infection by the virus present at a higher titer. Aside from CHIKV and ZIKV, coinfections of other viral pathogens were not detected. The mNGS approach is promising for differential diagnosis of acute febrile illness and identification of coinfections, although targeted arbovirus screening may be sufficient in the current ZIKV outbreak setting.

PMID:
27413190
PMCID:
PMC5005514
[Available on 2017-03-01]
DOI:
10.1128/JCM.00877-16
[Indexed for MEDLINE]
Free PMC Article

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