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Int J Epidemiol. 2016 Oct;45(5):1482-1492. Epub 2016 Jul 13.

Cumulative consumption of branched-chain amino acids and incidence of type 2 diabetes.

Zheng Y1, Li Y1, Qi Q2, Hruby A1, Manson JE3,4,5, Willett WC1,3,4, Wolpin BM6, Hu FB1,3,4, Qi L7,8.

Author information

1
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2
Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
3
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
4
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
5
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
6
Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
7
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA lqi1@tulane.edu.
8
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.

Abstract

BACKGROUND:

Plasma branched-chain amino acids (BCAAs, including leucine, isoleucine and valine) were recently related to risk of type 2 diabetes (T2D). Dietary intake is the only source of BCAAs; however, little is known about whether habitual dietary intake of BCAAs affects risk of T2D.

METHODS:

We assessed associations between cumulative consumption of BCAAs and risk of T2D among participants from three prospective cohorts: the Nurses' Health Study (NHS; followed from 1980 to 2012); NHS II (followed from 1991 to 2011); and the Health Professionals Follow-up Study (HPFS; followed from 1986 to 2010).

RESULTS:

We documented 16 097 incident T2D events during up to 32 years of follow-up. After adjustment for demographics and traditional risk factors, higher total BCAA intake was associated with an increased risk of T2D in men and women. In the meta-analysis of all cohorts, comparing participants in the highest quintile with those in the lowest quintile of intake, hazard ratios (95%confidence intervals) were for leucine 1.13 (1.07-1.19), for isoleucine 1.13 (1.07-1.19) and for valine 1.11 (1.05-1.17) (all P for trend < 0.001). In a healthy subsample, higher dietary BCAAs were significantly associated with higher plasma levels of these amino acids (P for trend = 0.01).

CONCLUSIONS:

Our data suggest that high consumption of BCAAs is associated with an increased risk of T2D.

KEYWORDS:

Diet; branched-chain amino acids; cohort study; type 2 diabetes

PMID:
27413102
PMCID:
PMC5100612
DOI:
10.1093/ije/dyw143
[Indexed for MEDLINE]
Free PMC Article

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