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Cancer Cell. 2016 Jul 11;30(1):9-10. doi: 10.1016/j.ccell.2016.06.018.

Modeling the Epigenetic Chain Reaction Downstream of DNMT3A(R882H).

Author information

1
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
2
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA. Electronic address: vakoc@cshl.edu.

Abstract

In this issue of Cancer Cell, Lu et al. use a mouse model of DNMT3A(R882H)/NRAS(G12D) acute myeloid leukemia to define a cascade of chromatin changes that emanate from DNMT3A-bound enhancers to initiate disease. The authors also reveal a chemical strategy to interrupt this process.

PMID:
27411582
DOI:
10.1016/j.ccell.2016.06.018
[Indexed for MEDLINE]
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