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Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT196-203. doi: 10.1167/iovs.15-18886.

Posterior Eye Shape Measurement With Retinal OCT Compared to MRI.

Author information

1
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States.
2
Singapore Eye Research Institute, The Academia, Singapore.
3
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
4
Memory Aging & Cognition Centre and Department of Pharmacology, National University of Singapore, Singapore.
5
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States 5Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States.
6
Singapore Eye Research Institute, The Academia, Singapore 6Duke-National University of Singapore (NUS) Graduate Medical School, Singapore, Singapore 7Singapore National Eye Centre, Singapore, Singapore.
7
Memory Aging & Cognition Centre and Department of Pharmacology, National University of Singapore, Singapore 8Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
8
Singapore Eye Research Institute, The Academia, Singapore 6Duke-National University of Singapore (NUS) Graduate Medical School, Singapore, Singapore.
9
Duke-National University of Singapore (NUS) Graduate Medical School, Singapore, Singapore 9University of Wisconsin-Madison, Department of Ophthalmology and Visual Sciences, Madison, Wisconsin, United States.

Abstract

PURPOSE:

Posterior eye shape assessment by magnetic resonance imaging (MRI) is used to study myopia. We tested the hypothesis that optical coherence tomography (OCT), as an alternative, could measure posterior eye shape similarly to MRI.

METHODS:

Macular spectral-domain OCT and brain MRI images previously acquired as part of the Singapore Epidemiology of Eye Diseases study were analyzed. The right eye in the MRI and OCT images was automatically segmented. Optical coherence tomography segmentations were corrected for optical and display distortions requiring biometry data. The segmentations were fitted to spheres and ellipsoids to obtain the posterior eye radius of curvature (Rc) and asphericity (Qxz). The differences in Rc and Qxz measured by MRI and OCT were tested using paired t-tests. Categorical assignments of prolateness or oblateness using Qxz were compared.

RESULTS:

Fifty-two subjects (67.8 ± 5.6 years old) with spherical equivalent refraction from +0.50 to -5.38 were included. The mean paired difference between MRI and original OCT posterior eye Rc was 24.03 ± 46.49 mm (P = 0.0005). For corrected OCT images, the difference in Rc decreased to -0.23 ± 2.47 mm (P = 0.51). The difference between MRI and OCT asphericity, Qxz, was -0.052 ± 0.343 (P = 0.28). However, categorical agreement was only moderate (κ = 0.50).

CONCLUSIONS:

Distortion-corrected OCT measurements of Rc and Qxz were not statistically significantly different from MRI, although the moderate categorical agreement suggests that individual differences remained. This study provides evidence that with distortion correction, noninvasive office-based OCT could potentially be used instead of MRI for the study of posterior eye shape.

PMID:
27409473
PMCID:
PMC4968781
DOI:
10.1167/iovs.15-18886
[Indexed for MEDLINE]
Free PMC Article

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