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Twin Res Hum Genet. 2016 Oct;19(5):418-21. doi: 10.1017/thg.2016.53. Epub 2016 Jul 13.

Two SNPs Associated With Spontaneous Dizygotic Twinning: Effect Sizes and How We Communicate Them.

Author information

1
Department of Biological Psychology,Vrije Universiteit,Amsterdam,the Netherlands.

Abstract

In a recent GWAS of spontaneous dizygotic twinning, Mbarek et al. (The American Journal of Human Genetics, 2016, Vol 98, pp. 898-908) identified two SNPs, rs11031006 (near FSHB) and rs17293443 (in SMAD3). In the present note, we address the question how to present the results in terms of effect sizes in a manner that is comprehensible to the general audience (e.g., mothers of twins, readership of newspapers). We propose to avoid the standard effect sizes such as odds ratios and relative risk as these require some knowledge of probability theory. Rather, we convey the results in terms of the conditional probabilities, but expressed in natural language.

KEYWORDS:

DZ twinning; effect size; genetic variants

PMID:
27406421
DOI:
10.1017/thg.2016.53
[Indexed for MEDLINE]

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