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Int J Food Sci Nutr. 2016 Dec;67(8):969-76. doi: 10.1080/09637486.2016.1207060. Epub 2016 Jul 12.

Effects of salicylic acid-induced wine rich in anthocyanins on metabolic parameters and adipose insulin signaling in high-fructose fed rats.

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a Laboratorio de Fisiopatología Cardiovascular, Facultad de Ciencias Médicas , Universidad Nacional de Cuyo , Mendoza , Argentina ;
b Instituto de Medicina y Biología Experimental de Cuyo (IMBECU)-CONICET , Mendoza , Argentina ;
c Laboratorio de Fisiología Vegetal , Instituto de Biología Agrícola Mendoza (IBAM), CONICET , Mendoza , Argentina ;
d Cátedra de Fisiología Vegetal, Universidad Nacional de Cuyo , Mendoza , Argentina.


We evaluated the effects of Syrah red wine treated with salicylic acid (RW SA) and its control red wine (RW) on metabolic parameters, systolic blood pressure and adipose tissue insulin signaling in high-fructose (F) fed rats. Grape treated with SA increased the anthocyanin (ANTs) levels in RW. F induced increased systolic blood pressure, dislipidemia and insulin resistance (HOMA:IR). F rats treated with RW significantly prevented these alterations while RW SA partially attenuated triglycerides levels and HOMA:IR without modifications in HDL cholesterol levels. F impaired the adipose tissue response to insulin. Supplementation with RW and RW SA partially attenuated these alterations. Rats supplemented with RW SA had lesser beneficial effects on metabolic alterations than control RW, while both RW and RW SA attenuated altered adipose response to insulin. More studies are necessary to deeply evaluate the effect on SA-induced RW rich in ANTs levels on metabolic alterations associated to MetS.


Salicylic acid; adipose tissue; anthocyanins; high-fructose diet; red wine

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