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Analyst. 2016 Aug 2;141(16):4855-8. doi: 10.1039/c6an00997b.

DNA-fueled molecular machine for label-free and non-enzymatic ultrasensitive detection of telomerase activity.

Author information

1
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. jren@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing 100039, China.
2
Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun, China.
3
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. jren@ciac.ac.cn.

Abstract

Herein, a non-enzymatic and label-free strategy based on DNA-fueled molecular machine was developed for ultrasensitive detection of telomerase activity in cancer cell extracts even at the single-cell level.

PMID:
27405851
DOI:
10.1039/c6an00997b
[Indexed for MEDLINE]

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