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J Infect Dis. 2016 Oct 15;214(suppl 3):S110-S121. Epub 2016 Jul 11.

An Outbreak of Ebola Virus Disease in the Lassa Fever Zone.

Author information

1
Viral Hemorrhagic Fever Program, Kenema Government Hospital.
2
Ministry of Health and Sanitation.
3
University of Sierra Leone.
4
Viral Hemorrhagic Fever Program, Kenema Government Hospital Ministry of Health and Sanitation.
5
Ministry of Social Welfare, Gender, and Children's Affairs.
6
World Health Organization Sierra Leone Ebola Response Team, Freetown, Sierra Leone Infectious Diseases Institute, Mulago Hospital Complex, Kampala, Uganda.
7
Section of Infectious Disease, Department of Pediatrics Section of Infectious Disease, Department of Internal Medicine, School of Medicine.
8
Section of Infectious Disease, Department of Pediatrics Section of Infectious Disease, Department of Internal Medicine, School of Medicine Department of Tropical Medicine.
9
Division of Allergy and Infectious Diseases, University of Washington, Seattle.
10
Corgenix, Broomfield, Colorado Zalgen Labs, Germantown, Maryland.
11
Department of Microbiology and Immunology.
12
Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston.
13
Zalgen Labs, Germantown, Maryland.
14
Scripps Translational Science Institute.
15
Broad Institute of MIT and Harvard.
16
NextGen Jane, San Francisco, California.
17
Department of Microbiology, Immunology, and Parasitology, LSU Health Mockingbird Nature Research Group, Pearl River, Louisiana.
18
Department of Biochemistry, Tulane University.
19
Department of Biostatistics and Bioinformatics, Tulane School of Public Health and Tropical Medicine.
20
Department of Immunology and Microbial Science.
21
Naval Engineering Facilities Command, Naples, Italy.
22
South Coast Solar.
23
Section of Infectious Disease, Department of Pediatrics Section of Infectious Disease, Department of Internal Medicine, School of Medicine Autoimmune Technologies, New Orleans.
24
Mount Sinai School of Medicine.
25
Autoimmune Technologies, New Orleans.
26
Corgenix, Broomfield, Colorado.
27
Vybion, Ithaca, New York, New York.
28
Department of Immunology and Microbial Science The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla.
29
Redeemer's University, Ede Irrua Specialist Teaching Hospital, Nigeria.
30
Irrua Specialist Teaching Hospital, Nigeria.
31
Broad Institute of MIT and Harvard Department of Organismic and Evolutionary Biology, Center for Systems Biology, Harvard University, Cambridge, Massachusetts.
32
Department of Microbiology and Immunology Zalgen Labs, Germantown, Maryland.

Abstract

BACKGROUND:

Kenema Government Hospital (KGH) has developed an advanced clinical and laboratory research capacity to manage the threat of Lassa fever, a viral hemorrhagic fever (VHF). The 2013-2016 Ebola virus (EBOV) disease (EVD) outbreak is the first to have occurred in an area close to a facility with established clinical and laboratory capacity for study of VHFs.

METHODS:

Because of its proximity to the epicenter of the EVD outbreak, which began in Guinea in March 2014, the KGH Lassa fever Team mobilized to establish EBOV surveillance and diagnostic capabilities.

RESULTS:

Augustine Goba, director of the KGH Lassa laboratory, diagnosed the first documented case of EVD in Sierra Leone, on 25 May 2014. Thereafter, KGH received and cared for numbers of patients with EVD that quickly overwhelmed the capacity for safe management. Numerous healthcare workers contracted and lost their lives to EVD. The vast majority of subsequent EVD cases in West Africa can be traced back to a single transmission chain that includes this first diagnosed case.

CONCLUSIONS:

Responding to the challenges of confronting 2 hemorrhagic fever viruses will require continued investments in the development of countermeasures (vaccines, therapeutic agents, and diagnostic assays), infrastructure, and human resources.

KEYWORDS:

Ebola virus; Lassa virus; West African Ebola outbreak 2013–16; epidemiology; genomic sequencing; research capacity building; viral hemorrhagic fever diagnostics

PMID:
27402779
PMCID:
PMC5050470
DOI:
10.1093/infdis/jiw239
[Indexed for MEDLINE]
Free PMC Article

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