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J Neurochem. 2016 Oct;139 Suppl 1:318-324. doi: 10.1111/jnc.13691. Epub 2016 Jul 11.

The clinical symptoms of Parkinson's disease.

Author information

1
Department of Neurology, Broomfield Hospital, Chelmsford, Essex, CM1 7ET, UK. sigurlaug.sveinbjornsdottir@meht.nhs.uk.
2
Queen Mary School of Medicine and Dentistry, University of London, London, UK. sigurlaug.sveinbjornsdottir@meht.nhs.uk.

Abstract

In this review, the clinical features of Parkinson's disease, both motor and non-motor, are described in the context of the progression of the disease. Also briefly discussed are the major treatment strategies and their complications. Parkinson's disease is a slowly progressing neurodegenerative disorder, causing impaired motor function with slow movements, tremor and gait and balance disturbances. A variety of non-motor symptoms are common in Parkinson's disease. They include disturbed autonomic function with orthostatic hypotension, constipation and urinary disturbances, a variety of sleep disorders and a spectrum of neuropsychiatric symptoms. This article describes the different clinical symptoms that may occur and the clinical course of the disease. This article is part of a special issue on Parkinson disease.

KEYWORDS:

Parkinson's disease; clinical symptoms; dopamine; therapy

PMID:
27401947
DOI:
10.1111/jnc.13691
[Indexed for MEDLINE]
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