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J Cereb Blood Flow Metab. 2017 Jun;37(6):2002-2012. doi: 10.1177/0271678X16659302. Epub 2016 Jan 1.

Sustained diffusion reversal with in-bore reperfusion in monkey stroke models: Confirmed by prospective magnetic resonance imaging.

Author information

1
1 Department of Radiology, Chungbuk National University Hospital, Chungbuk, Republic of Korea.
2
2 National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Republic of Korea.
3
3 Medical Research Institute, Chung-Ang University, Seoul, Korea.
4
4 Clinical Science, Philips Healthcare, Seoul, Republic of Korea.
5
5 College of Medicine, Chungbuk National University, Chungbuk, Republic of Korea.

Abstract

Although early diffusion lesion reversal after recanalization treatment of acute ischaemic stroke has been observed in clinical settings, the reversibility of lesions observed by diffusion-weighted imaging remains controversial. Here, we present consistent observations of sustained diffusion lesion reversal after transient middle cerebral artery occlusion in a monkey stroke model. Seven rhesus macaques were subjected to endovascular transient middle cerebral artery occlusion with in-bore reperfusion confirmed by repeated prospective diffusion-weighted imaging. Early diffusion lesion reversal was defined as lesion reversal at 3 h after reperfusion. Sustained diffusion lesion reversal was defined as the difference between the ADC-derived pre-reperfusion maximal ischemic lesion volume (ADCD-P Match) and the lesion on 4-week follow-up FLAIR magnetic resonance imaging. Diffusion lesions were spatiotemporally assessed using a 3-D voxel-based quantitative technique. The ADCD-P Match was 9.7 ± 6.0% (mean ± SD) and the final infarct was 1.2-6.0% of the volume of the ipsilateral hemisphere. Early diffusion lesion reversal and sustained diffusion lesion reversal were observed in all seven animals, and the calculated percentages compared with their ADCD-P Match ranged from 8.3 to 51.9% (mean ± SD, 26.9 ± 15.3%) and 41.7-77.8% (mean ± SD, 65.4 ± 12.2%), respectively. Substantial sustained diffusion lesion reversal and early reversal were observed in all animals in this monkey model of transient focal cerebral ischaemia.

KEYWORDS:

Animal model; brain imaging; brain ischaemia; brain recovery; diffusion-weighted magnetic resonance imaging

PMID:
27401804
PMCID:
PMC5464696
DOI:
10.1177/0271678X16659302
[Indexed for MEDLINE]
Free PMC Article

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