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Elife. 2016 Jul 11;5. pii: e17023. doi: 10.7554/eLife.17023.

Integration of light and metabolic signals for stem cell activation at the shoot apical meristem.

Author information

1
Department of Stem Cell Biology, Centre for Organismal Studies, Heidelberg University, Heidelberg, Germany.
2
Department of Molecular Plant Biology, Centre for Organismal Studies, Heidelberg University, Heidelberg, Germany.
3
Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen, Germany.

Abstract

A major feature of embryogenesis is the specification of stem cell systems, but in contrast to the situation in most animals, plant stem cells remain quiescent until the postembryonic phase of development. Here, we dissect how light and metabolic signals are integrated to overcome stem cell dormancy at the shoot apical meristem. We show on the one hand that light is able to activate expression of the stem cell inducer WUSCHEL independently of photosynthesis and that this likely involves inter-regional cytokinin signaling. Metabolic signals, on the other hand, are transduced to the meristem through activation of the TARGET OF RAPAMYCIN (TOR) kinase. Surprisingly, TOR is also required for light signal dependent stem cell activation. Thus, the TOR kinase acts as a central integrator of light and metabolic signals and a key regulator of stem cell activation at the shoot apex.

KEYWORDS:

<i>a. thaliana</i>; TOR kinase; WUSCHEL; developmental biology; light signaling; metabolic signaling; plant biology; stem cell activation; stem cells

PMID:
27400267
PMCID:
PMC4969040
DOI:
10.7554/eLife.17023
[Indexed for MEDLINE]
Free PMC Article

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