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Clin Exp Immunol. 2016 Nov;186(2):144-156. doi: 10.1111/cei.12840. Epub 2016 Aug 12.

Interleukin (IL)-39 [IL-23p19/Epstein-Barr virus-induced 3 (Ebi3)] induces differentiation/expansion of neutrophils in lupus-prone mice.

Author information

1
Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China. wang_renxi@yahoo.com.
2
Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.
3
Department of Nephrology, the 307th Hospital of Chinese People's Liberation Army, Beijing, China.
4
College of Pharmacy, Henan University, Kaifeng, China.
5
Department of Biomedicine, Institute of Frontier Medical Sciences, School of Pharmaceutical Sciences, Jilin University, Changchun, China.
6
Laboratory of Cellular and Molecular Immunology, Henan University, Kaifeng, Henan, China.
7
Department of Rheumatology, First Hospital of Jilin University, Changchun, China.
8
Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China. yinher2001@yahoo.com.

Abstract

Interleukin (IL)-12 family cytokines play critical roles in autoimmune diseases. Our previous study has shown that IL-23p19 and Epstein-Barr virus-induced 3 (Ebi3) form a new IL-12 family heterodimer, IL-23p19/Ebi3, termed IL-39, and knock-down of p19 or Ebi3 reduced diseases by transferred GL7+ B cells in lupus-prone mice. In the present study, we explore further the possible effect of IL-39 on murine lupus. We found that IL-39 in vitro and in vivo induces differentiation and/or expansion of neutrophils. GL7+ B cells up-regulated neutrophils by secreting IL-39, whereas IL-39-deficient GL7+ B cells lost the capacity to up-regulate neutrophils in lupus-prone mice and homozygous CD19cre (CD19-deficient) mice. Finally, we found that IL-39-induced neutrophils had a positive feedback on IL-39 expression in activated B cells by secreting B cell activation factor (BAFF). Taken together, our results suggest that IL-39 induces differentiation and/or expansion of neutrophils in lupus-prone mice.

KEYWORDS:

BAFF; IL-39; autoimmune diseases; lupus; neutrophils

PMID:
27400195
PMCID:
PMC5054574
DOI:
10.1111/cei.12840
[Indexed for MEDLINE]
Free PMC Article

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