Two new sesquiterpenes from Chloranthus japonicus Sieb

Nat Prod Res. 2016 Nov;30(21):2476-82. doi: 10.1080/14786419.2016.1205050. Epub 2016 Jul 11.

Abstract

Two new sesquiterpenes, namely, 1β,10β-dihydroxy-eremophil-7(11), 8-dien-12,8-olide (1) and 8,12-epoxy-1β-hydroxyeudesm-3,7,11-trien-9-one (2), together with three known sesquiterpenoids, shizukolidol (3), 4α-hydroxy-5α(H)-8β-methoxy-eudesm-7(11)-en-12,8-olide (4), and neolitacumone B (5), and two known monoterpenes, (3R,4S,6R)-p-menth-1-en-3,6-diol (6) and (R)-p-menth-1-en-4,7-diol (7), were isolated from the whole plant of Chloranthus japonicus Sieb. Their structures were elucidated on the basis of spectroscopic data analysis and comparison with those of related known compounds. Compounds 4-7 were isolated from this plant for the first time.

Keywords: Chloranthus japonicus; monoterpenes; sesquiterpenes.

MeSH terms

  • Animals
  • Artemia / drug effects
  • Magnoliopsida / chemistry*
  • Medicine, Chinese Traditional
  • Plant Extracts / analysis
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / toxicity

Substances

  • Plant Extracts
  • Sesquiterpenes
  • neolitacumone B