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Nat Struct Mol Biol. 2016 Aug;23(8):752-4. doi: 10.1038/nsmb.3258. Epub 2016 Jul 11.

Structure of the NS3 helicase from Zika virus.

Author information

1
Department of Structural &Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
2
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
3
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
4
Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Abstract

Zika virus has emerged as a pathogen of major health concern. Here, we present a high-resolution (1.62-Å) crystal structure of the RNA helicase from the French Polynesia strain. The structure is similar to that of the RNA helicase from Dengue virus, with variability in the conformations of loops typically involved in binding ATP and RNA. We identify druggable 'hotspots' that are well suited for in silico and/or fragment-based high-throughput drug discovery.

PMID:
27399257
PMCID:
PMC5085289
DOI:
10.1038/nsmb.3258
[Indexed for MEDLINE]
Free PMC Article

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