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Nature. 1989 Jul 13;340(6229):122-6.

Mapping the transition state and pathway of protein folding by protein engineering.

Author information

1
MRC Unit for Protein Function and Design, University of Cambridge, UK.

Abstract

In the transition state for unfolding of barnase, the hydrophobic core between the major alpha-helix and beta-sheet is somewhat weakened, the C terminus of the major helix is largely intact but its N terminus is exposed and a major loop has been invaded by solvent.

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PMID:
2739734
DOI:
10.1038/340122a0
[Indexed for MEDLINE]

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