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Nature. 1989 Jul 6;340(6228):35-41.

Expression of a large family of POU-domain regulatory genes in mammalian brain development.

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1
Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093-0613.

Erratum in

  • Nature 1989 Aug 24;340(6235):662.

Abstract

A novel region referred to as the POU-domain is present in two tissue-specific transcription factors, Pit-1 and Oct-2, that activate expression of genes specifying pituitary and lymphocyte phenotypes. We report the identification of multiple new members of a large family of POU-domain genes expressed in adult brain, and document that all the known mammalian POU-domain genes, including Pit-1 and Oct-2, are expressed widely in the developing nervous system.

PMID:
2739723
DOI:
10.1038/340035a0
[Indexed for MEDLINE]
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