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J Neuroimmunol. 2016 Aug 15;297:20-7. doi: 10.1016/j.jneuroim.2016.05.008. Epub 2016 May 10.

Alpha-mangostin attenuates brain inflammation induced by peripheral lipopolysaccharide administration in C57BL/6J mice.

Author information

1
Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico (UNAM), Apartado Postal 70228, Cuidad Universitaria, Mexico, DF 04510, Mexico.
2
Departamento de Biologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico (UNAM), Apartado Postal 70228, Cuidad Universitaria, Mexico, DF, 04510, Mexico.
3
Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico (UNAM), Apartado Postal 70228, Cuidad Universitaria, Mexico, DF 04510, Mexico. Electronic address: gokar@unam.mx.

Abstract

Neuroinflammation is an important feature in the pathogenesis and progression of neurodegenerative diseases. Molecules with anti-inflammatory properties have been evaluated in animal models of neuroinflammation and neurodegeneration as an adjuvant therapeutic strategy. In the present study we have demonstrated that alpha-mangostin (α-MG), a natural xanthone purified from mangosteen pericarp, reduced brain levels of pro-inflammatory cytokine interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and 18 kDa translocator protein (TSPO) in an animal model of peripheral LPS-induced neuroinflammation. We think that evaluation of α-MG as an adjuvant treatment in preclinical models of AD, PD, multiple sclerosis and other diseases with known shared pathology merits further consideration.

KEYWORDS:

Cyclooxygenase-2; Interleukin-6; Lipopolysaccharide; Neuroinflammation; Peripheral infection; α-Mangostin

PMID:
27397072
DOI:
10.1016/j.jneuroim.2016.05.008
[Indexed for MEDLINE]

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