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Nat Rev Microbiol. 2016 Aug;14(8):479-93. doi: 10.1038/nrmicro.2016.87. Epub 2016 Jul 11.

Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis.

Author information

1
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

Abstract

The genomes of influenza viruses consist of multiple segments of single-stranded negative-sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent RNA polymerase and multiple copies of nucleoprotein, which form viral ribonucleoprotein (vRNP) complexes. It is in the context of these vRNPs that the viral RNA polymerase carries out transcription of viral genes and replication of the viral RNA genome. In this Review, we discuss our current knowledge of the structure of the influenza virus RNA polymerase, and insights that have been gained into the molecular mechanisms of viral transcription and replication, and their regulation by viral and host factors. Furthermore, we discuss how advances in our understanding of the structure and function of polymerases could help in identifying new antiviral targets.

PMID:
27396566
PMCID:
PMC4966622
DOI:
10.1038/nrmicro.2016.87
[Indexed for MEDLINE]
Free PMC Article

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