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CNS Drugs. 2016 Oct;30(10):889-97. doi: 10.1007/s40263-016-0369-9.

Therapeutic Potential of Genipin in Central Neurodegenerative Diseases.

Author information

1
Key Laboratory of Cellular Physiology, Medical Faculty, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China.
2
Department of Human Anatomy, Shaoyang Medical College, Shaoyang, Hunan, People's Republic of China.
3
Key Laboratory of Cellular Physiology, Medical Faculty, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. linlilin999@163.com.
4
Biomedical and Life Science, Faculty of Health and Medicine, Lancaster University, Lancaster, LA1 4YQ, UK.
5
Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, People's Republic of China.

Abstract

Central neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), are one of the biggest health problems worldwide. Currently, there is no cure for these diseases. The Gardenia jasminoides fruit is a common herbal medicine in traditional Chinese medicine (TCM), and a variety of preparations are used as treatments for central nervous system (CNS) diseases. Pharmacokinetic studies suggest genipin is one of the main effective ingredients of G. jasminoides fruit extract (GFE). Accumulated research data show that genipin possesses a range of key pharmacological properties, such as anti-inflammatory, neuroprotective, neurogenic, antidiabetic, and antidepressant effects. Thus, genipin shows therapeutic potential for central neurodegenerative diseases. We review the pharmacological actions of genipin for the treatment of neurodegenerative diseases of the CNS. We also describe the potential mechanisms underlying these effects.

PMID:
27395402
DOI:
10.1007/s40263-016-0369-9
[Indexed for MEDLINE]

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