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Cell Immunol. 2016 Nov;309:32-36. doi: 10.1016/j.cellimm.2016.06.004. Epub 2016 Jun 29.

Pathways leading to interleukin-12 production and protective immunity in cutaneous leishmaniasis.

Author information

1
Department of Immunology, Rady Faculty of Health Sciences, College of Medicine, University of Manitoba, Winnipeg R3E 0T5, Canada. Electronic address: Ifeoma.okwor@umanitoba.ca.
2
Department of Immunology, Rady Faculty of Health Sciences, College of Medicine, University of Manitoba, Winnipeg R3E 0T5, Canada.

Abstract

Leishmaniasis affects millions of people worldwide and continues to pose public health problem. There is extensive evidence supporting the critical role for IL-12 in initiating and maintaining protective immune response to Leishmania infection. Although gene deletion studies show that CD40-CD40L interaction is an important pathway for IL-12 production by antigen-presenting cells and subsequent development of protective immunity in cutaneous leishmaniasis, several studies have uncovered other pathways that could also lead to IL-12 production and immunity in the absence of intact CD40-CD40L signaling. Here, we review the literature on the role of IL-12 in the induction and maintenance of protective T cell-mediated immunity in cutaneous leishmaniasis and the different pathways leading to IL-12 production by antigen-presenting cells following Leishmania major infection.

KEYWORDS:

CD40; CD40 ligand; IL-12; Immunity; Infection; Leishmania major; Macrophage antigen 1; Th1 response

PMID:
27394077
DOI:
10.1016/j.cellimm.2016.06.004
[Indexed for MEDLINE]

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