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Curr Opin Struct Biol. 2016 Dec;41:98-108. doi: 10.1016/j.sbi.2016.06.009. Epub 2016 Jul 6.

The intraflagellar transport machinery in ciliary signaling.

Author information

1
Department of Structural Cell Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.
2
Department of Biology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark. Electronic address: stchristensen@bio.ku.dk.
3
Department of Structural Cell Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany. Electronic address: lorentze@biochem.mpg.de.

Abstract

Cilia and flagella on eukaryotic cells are slender microtubule-based projections surrounded by a membrane with a unique lipid and protein composition. It is now appreciated that cilia in addition to their established roles in motility also constitute hubs for cellular signaling by sensing external environmental cues necessary for organ development and maintenance of human health. Pathways reported to rely on the cilium organelle include Hedgehog, TGF-β, Wnt, PDGFRα, integrin and DNA damage repair signaling. An emerging theme in ciliary signaling is the requirement for active transport of signaling components into and out of the cilium proper. Here, we review the current state-of-the-art regarding the importance of intraflagellar transport and BBSome multi-subunit complexes in ciliary signaling.

PMID:
27393972
DOI:
10.1016/j.sbi.2016.06.009
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