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Adv Healthc Mater. 2016 Sep;5(18):2339-44. doi: 10.1002/adhm.201600588. Epub 2016 Jul 8.

Programmed Nanoparticles for Tailoring the Detection of Inflammatory Bowel Diseases and Irritable Bowel Syndrome Disease via Breathprint.

Author information

1
Internal Medicine C and Gastroenterology Departments at Rambam Medical Center, Rappaport School of Medicine at Technion-Israel Institute of Technology, Haifa, 3109610, Israel.
2
Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.
3
Department of Chemical Engineering, Complutense University of Madrid, Madrid, 28040, Spain.
4
Department of Gastroenterology at Bnai Zion Hospital, Rappaport School of Medicine at Technion-Israel Institute of Technology, Haifa, 31048, Israel.
5
Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, 3200003, Israel. hhossam@technion.ac.il.

Abstract

Chemical sensors based on programmable molecularly modified gold nanoparticles are tailored for the detection and discrimination between the breathprint of irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD). The sensors are examined in both lab- and real-world clinical conditions. The results reveal a discriminative power accuracy of 81% between IBD and IBS and 75% between Crohn's and Colitis states.

KEYWORDS:

breathprint; diagnosis; inflammatory bowel disease; irritable bowel syndrome; nanoparticles; sensors

PMID:
27390291
DOI:
10.1002/adhm.201600588
[Indexed for MEDLINE]

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