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Andrologia. 2017 May;49(4). doi: 10.1111/and.12630. Epub 2016 Jul 8.

Testosterone replacement therapy improves health-related quality of life for patients with late-onset hypogonadism: a meta-analysis of randomized controlled trials.

Author information

1
Department of Urology, The Second Xiangya Hospital, Central South University, Yuhua District, Changsha City, Hunan, China.
2
Department of Urology, Shekou People's Hospital, Nanshan District, Shenzhen City, Guangdong Province, China.

Abstract

Although testosterone replacement therapy can restore serum testosterone concentrations to normal level in late-onset hypogonadism patients, whether it can improve patients' quality of life remains uncertain. Therefore, we perform a meta-analysis of randomized controlled trials on this issue. Five randomized controlled trials total 1,212 patients were included. Fixed-effect model was used to calculate the weighted mean difference of score of Aging Males' Symptom rating scale. Our result reveals that testosterone replacement therapy improves patients' health-related quality of life in terms of the decrease in the AMS total score [WMD = -2.96 (-4.21, -1.71), p < .00001] and the psychological [WMD = -0.89 (-1.41, -0.37), p = .0008], somatic [WMD = -0.89 (-1.41, -0.37), p = .0008] and sexual [WMD = -1.29 (-1.75, -0.83), p < .00001] subscale score.

KEYWORDS:

Aging Males' Symptom rating scale; health-related quality of life; late-onset hypogonadism; testosterone deficiency; testosterone replacement therapy

PMID:
27389320
DOI:
10.1111/and.12630
[Indexed for MEDLINE]

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