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Andrologia. 2017 May;49(4). doi: 10.1111/and.12630. Epub 2016 Jul 8.

Testosterone replacement therapy improves health-related quality of life for patients with late-onset hypogonadism: a meta-analysis of randomized controlled trials.

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Department of Urology, The Second Xiangya Hospital, Central South University, Yuhua District, Changsha City, Hunan, China.
Department of Urology, Shekou People's Hospital, Nanshan District, Shenzhen City, Guangdong Province, China.


Although testosterone replacement therapy can restore serum testosterone concentrations to normal level in late-onset hypogonadism patients, whether it can improve patients' quality of life remains uncertain. Therefore, we perform a meta-analysis of randomized controlled trials on this issue. Five randomized controlled trials total 1,212 patients were included. Fixed-effect model was used to calculate the weighted mean difference of score of Aging Males' Symptom rating scale. Our result reveals that testosterone replacement therapy improves patients' health-related quality of life in terms of the decrease in the AMS total score [WMD = -2.96 (-4.21, -1.71), p < .00001] and the psychological [WMD = -0.89 (-1.41, -0.37), p = .0008], somatic [WMD = -0.89 (-1.41, -0.37), p = .0008] and sexual [WMD = -1.29 (-1.75, -0.83), p < .00001] subscale score.


Aging Males' Symptom rating scale; health-related quality of life; late-onset hypogonadism; testosterone deficiency; testosterone replacement therapy

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