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Eur Heart J Acute Cardiovasc Care. 2018 Mar;7(2):120-128. doi: 10.1177/2048872616658591. Epub 2016 Jul 7.

High-sensitivity cardiac troponin assays and unstable angina.

Author information

1
1 Division of Cardiology, Department of Medicine, Hennepin County Medical Center, Minneapolis, MN, USA.
2
2 Minneapolis Heart Institute, Abbott-Northwestern Hospital, Minneapolis, MN, USA.
3
3 Department of Laboratory Medicine and Pathology, Hennepin County Medical Center and University of Minnesota, Minneapolis, MN, USA.
4
4 Department of Emergency Medicine, Hennepin County Medical Center and University of Minnesota, Minneapolis, MN, USA.

Abstract

The term unstable angina has been conventionally applied to patients with myocardial ischemia without myocardial necrosis. However, while the clinical context has remained constant over time, the biomarkers of myocardial injury and acute myocardial infarction have evolved. High-sensitivity cardiac troponin assays have several key analytical differences from prior cardiac troponin assay generations, which may alter the diagnosis and frequency of unstable angina, as well as affect our understanding of previously developed risk stratification strategies. This document reviews the current challenges in regards to unstable angina when using high-sensitivity cardiac troponin I and T assays.

KEYWORDS:

Unstable angina; acute coronary syndrome; cardiac troponin; high-sensitivity cardiac troponin; myocardial infarction

PMID:
27388716
DOI:
10.1177/2048872616658591
[Indexed for MEDLINE]

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