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Sci Adv. 2016 May 27;2(5):e1600200. doi: 10.1126/sciadv.1600200. eCollection 2016 May.

Fundamentals of cancer metabolism.

Author information

1
Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
2
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Abstract

Tumors reprogram pathways of nutrient acquisition and metabolism to meet the bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed activities are now recognized as hallmarks of cancer, and recent work has uncovered remarkable flexibility in the specific pathways activated by tumor cells to support these key functions. In this perspective, we provide a conceptual framework to understand how and why metabolic reprogramming occurs in tumor cells, and the mechanisms linking altered metabolism to tumorigenesis and metastasis. Understanding these concepts will progressively support the development of new strategies to treat human cancer.

KEYWORDS:

Cancer; ROS; glycolysis; metabolism; mitochondria; oncogenes

PMID:
27386546
PMCID:
PMC4928883
DOI:
10.1126/sciadv.1600200
[Indexed for MEDLINE]
Free PMC Article

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